Gene editing, its true potential and the dangers ahead

Join us on April 15th at 10:00am PT (San Francisco) for this free Cota Access online event to discuss the CRISPR gene editing technique, its true potential, and the dangers ahead.

CRISPR-Cas9, or simply CRISPR, a genome editing technique, has generated a lot of excitement in the scientific community. It relies on a sequence-specific guide RNA to direct a scissor-like, bacterial enzyme (Cas9) to just the right spot in the genome, where it can be used to cut out, replace, or repair disease-causing mutations. …

Have you ever received an email from noreply@ your-company-of-choice dot com? Of course. How many times? Hundreds of times? Thousands of times?

Truth is, companies don’t want to hear from you. They just want you to pay and shut up.

Companies don’t want to hear from you.

They just want you to pay and shut up.

The “noreply@” phenomenon is simple and it’s also very stupid: a company tells you something, but doesn’t give you the opportunity to reply.

By adding friction to your ability to reply (you need to waste time trying to figure out how to contact them)…

Going Viral: The Future of Human Health, Pandemic Resilience and Biowarfare

Join us to discuss the most important topic of last year, of this year, and possibly every future year to come. COVID-19. Viruses. mRNA Vaccines. Synthetic Biology. Pandemic Resilience. And the very real threats and opportunities around Biosecurity and Biowarfare.

Register for this event here.

We have two rockstar speakers joining us for what promises to be a discussion for the ages. Milana Boukhman Trounce, MD, MBA and Gigi Kwik Gronvall, PhD have been leading key COVID-19 initiatives at their respective institutions, Stanford and Johns Hopkins. They teach, research, speak, lead, and generally drop the mic on all things “viral.”

Someone is wrong on the internet (source)

The problem

Bitcoins are created out of thin air from a computing process called “mining”, a term inspired by how precious metals are extracted from Earth’s crust. In reality, this “mining” is a computationally intensive task with an artificial level of difficulty, required to reach consensus on which “block” in the blockchain gets validated next (on average every 10 minutes). It’s also called Proof-of-Work.

The same computing process also validates ~4 transactions per second, or ~300,000 per day, or ~110M transactions per year (source).

This network of Bitcoin nodes currently consumes ~77 TWh per year (source). …

I am a big fan of Stripe, and I was recently thinking that there’s a non-obvious opportunity for them to fix one of the most annoying thing ever: customer service. I tried to imagine what an internal memo on the subject should look like. Wrote it. And decided to share it with you. Hope you find it interesting; most “corporate strategy” activity like this one is often kept secret, and there aren’t enough opportunities to discuss it openly. This is my humble contribution to this needed discussion. Read on.

Old photo of mine from 2015, just because a wall of text without any picture scares people too much.

Customer Service is currently an inefficient business function that damages the…

This is what happens on the Internet today.
I can only call it insanity.

You know what it is. It has happened to you, too. But the more I see it, the harder it is to believe that this is what the Internet has become.

Try to visit this page (it could be anything else), and this is what you get.

And of course YOU are supposed to scroll through everything, block everything, etc. As I said, insanity.

Here’s the full, yes FULL, copy&paste of it, just for completeness. …

Fred Wilson, a VC (Venture Capitalist) I quite like and admire, talks about Mentors, in particular about the two mentors that shaped his professional life. Here’s two important passages (bold is mine):

Angela Merkel, LeBron James, Oprah Winfrey, Jeff Bezos … Nobody gets somewhere on their own. Everyone has help.

And then, further down in his blog post:

The thing about mentors is you can’t really ask someone to mentor you. It kind of happens organically. Someone takes you under their wing. They see something in you and want to bring it out, develop it.

I agree. But I think…

(originally published in my newsletter)

Bitcoin is a hot topic these days.

I have discussed Bitcoin or other crypto projects at least a few dozen times during 2020, and most of the time I have witnessed (or experienced) a real difficulty in having a good grasp of the underlying technology.

I believe that the vast majority of people, even technical people like me, do not have a deep understanding of it; I also believe that we are not going to fix this with (otherwise excellent, but long) videos on how Bitcoin works.

I tried to come up with a way…

Do you want to know how to read 50 books a year?


There are 52.14 weeks in a given year. (and an extra “bonus” day on leap years, making it 52.28 weeks). Read one book per week. Keep the 2.14 weeks as “margin”, for times when you really can’t or won’t read. If a book is really thick (>300 pages, and/or really dense), count it as two books.

Wait, I’m not done yet.

Tell a few friends about it. Commit to writing a very, very short review of the book (could be a single 280-characters tweet, or three sentences)…

You might have noticed that in the past several weeks I have been busy interviewing people for the newly born “Cota Capital Podcast”. I’d like to share the WHY a podcast first; limitations of podcasts; and the few episodes that I’ve published so far, with the not-too-hidden agenda of driving some nice, interested traffic (I call it “honest traffic”) to these episodes, certain that you will find these interesting.

My messy but very productive setup. The Docker shirt was a gift from Solomon. I was a fan of Docker back then.

Who’s Cota Capital?

I am an Operating Partner at Cota Capital Management, LLC.
Cota is an SEC-registered multi-stage investment firm focused on private and public modern enterprise technology companies. Based in San Francisco, Cota…

Simone Brunozzi

Tech, startups and investments. Global life. Italian heart.

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